BIO

  • Chemical Properties
CAS No. 667463-62-9 Cat. No. BCP07234
Name BIO
Synonyms GSK-3 Inhibitor IX;GSK 3 IX ; 6BIO; MLS 2052; MLS-2052; MLS2052;
Formula C16H10BrN3O2 M. Wt 356.17
  • Biological Activity
Description Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes.
Pathways Cell Cycle/DNA Damage PI3K/Akt/mTOR Wnt/Stem Cell 
Targets GSK3 CDK 

Structure

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