RO3280
| CAS号 | 1062243-51-9 | 货号 | BCP07189 |
| 中文名 | RO3280 | ||
| 英文名 | RO3280 | ||
| 中文别名 | |||
| 英文别名 | Ro5203280; Ro-5203280; Ro 5203280; RO5203280; | ||
| 分子式 | C27H35F2N7O3 | 分子量 | 543.61 |
| 生物活性 | Ro5203280 is a small-molecular PLK1 inhibitor that is structurally similar to BI2536, but with improved activity. R05203280 exhibits a high selectivity and shows a very low Kd (0.09 nmol/L) to PLK1 when compared with the 0.2 nmol/L Kd of BI2536. Ro5203280 also exhibits potent and broad activity in suppressing a large panel of 30 cell lines with IC50 as low as 6 nmol/L. Ro5203280 shows a high efficacy for suppressing nasopharyngeal carcinoma growth with low toxicity in mouse studies. It suppresse | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PLK | ||
结构式
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