PF-05089771
| CAS No. | 1235403-62-9 | Cat. No. | BCP07066 |
| Name | PF-05089771 | ||
| Synonyms | PF-05089771; PF 05089771; PF05089771; PF-05089771; PF05089771; PF 05089771; | ||
| Formula | C18H12Cl2FN5O3S2 | M. Wt | 500.34 |
| Description | PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a slow onset of block that is depolarization and concentration dependent, with a similarly slow recovery from block. Human hereditary gain- or loss-of-pain disorders have demonstrated an essential role of Nav1.7 sodium channels in the sensation of pain, thus making this channel an attractive target for new pain therapies. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Sodium Channel | ||
Structure
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