Etoposide phosphate
| CAS No. | 117091-64-2 | Cat. No. | BCP07045 |
| Name | Etoposide phosphate | ||
| Synonyms | Etopofos;BMY 40481; | ||
| Formula | C29H33O16P | M. Wt | 668.54 |
| Description | Etoposide Phosphate is a derivative of Etoposide (VP-16). Etoposide is a topoisomerase II inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties. Inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Cell-cycle dependent and cell-cycle specific to late S and G2 phases. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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