PTACH
| CAS No. | 848354-66-5 | Cat. No. | BCP06994 |
| Name | PTACH | ||
| Synonyms | NCH51;NCH-51;NCH 51; | ||
| Formula | C20H26N2O2S2 | M. Wt | 390.57 |
| Description | PTACH, also known as NCH-51, is a histone deacetylase (HDAC) inhibitor. NCH-51 tnhibits growth of various cancer cells in vitro (EC50 = 1.1 - 9.1 μM). NCH-51 could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. NCH-51 upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. NCH-51 exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | HDAC | ||
Structure
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