Exendin-4

  • Chemical Properties
CAS No. 141758-74-9 Cat. No. BCP06982
Name Exendin-4
Synonyms Exenatide;
Formula C184H282N50O60S M. Wt 4186.57
  • Biological Activity
Description Exendin-4 stimulates proliferation of HCAECs through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1(glucagon-like peptide-1) receptor-dependent mechanism. Exendin-4, the long-acting GLP-1 receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus treatment. Studies also demonstrated its neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases.
Pathways GPCR/G Protein 
Targets Glucagon Receptor 

Structure

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