Cyclosporin A
| CAS No. | 59865-13-3 | Cat. No. | BCP06979 |
| Name | Cyclosporin A | ||
| Synonyms | Cyclosporine; Ciclosporin; | ||
| Formula | C62H111N11O12 | M. Wt | 1202.61 |
| Description | Cyclosporin A binds to the cyclophilin (immunophilin) in T cells, forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. Cyclosporin A inhibits calcineurin with IC50 of 7 nM, then blocks the nuclear translocation of NF-AT. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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