Lucitanib hydrochloride
| CAS No. | 1058137-84-0 | Cat. No. | BCP21230 |
| Name | Lucitanib hydrochloride | ||
| Synonyms | E-3810 HCI;E3810; E-3810; E 3810; AL3810; AL 3810; AL-3810; | ||
| Formula | C26H25N3O4.HCl | M. Wt | 479.95 |
| Description | Lucitanib is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | VEGFR FGFR | ||
Structure
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