Miglustat

CAS No.	72599-27-0	Cat. No.	BCP06903
Name	Miglustat
Synonyms	OGT918; OGT 918; OGT-918;SC-48334;SC48334;SC 48334;N-Butyldeoxynojirimycin;NB-DNJ;
Formula	C10H21NO4	M. Wt	219.28

Description	Miglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first step of glycosphingolipid biosynthesis and is currently approved for the oral treatment of type 1 GD. Consumption of a standard high-fat breakfast within 30 minutes before administration of miglustat significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to miglustat. The peak plasma concentration (C(max)) decreased by 36% on average following administration with food. Area under the plasma concentration-time curve (AUC(0-infinity)) showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. The median (min-max) time to C(max) (t(max)) was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food.
Pathways	Others Pathway
Targets	Others

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