阿卡地新
| CAS号 | 2627-69-2 | 货号 | BCP06900 |
| 中文名 | 阿卡地新 | ||
| 英文名 | Acadesine | ||
| 中文别名 | |||
| 英文别名 | GP 1 110; ARA100; ARA-100; ARA 100; SCH-900395; SCH 900395; SCH900395; AICA ribofuranoside;AICAR; AICA-riboside; | ||
| 分子式 | C9H14N4O5 | 分子量 | 258.23 |
| 生物活性 | AICAR is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia[2] and may have applications in treating other disorders such as diabetes. Acadesine is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis. | ||
| 信号通路 | PI3K/Akt/mTOR Epigenetics | ||
| 靶 点 | AMPK | ||
结构式
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