Fimepinostat
| CAS No. | 1339928-25-4 | Cat. No. | BCP06870 |
| Name | Fimepinostat | ||
| Synonyms | CUDC907; CUDC 907;CUDC-907; | ||
| Formula | C23H24N8O4S | M. Wt | 508.55 |
| Description | Fimepinostat is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, fimepinostat inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR Epigenetics | ||
| Targets | HDAC PI3K | ||
Structure
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