GO6976

  • Chemical Properties
CAS No. 136194-77-9 Cat. No. BCP06797
Name GO6976
Synonyms GO-6976;GO 6976; PD406976; PD 406976; PD-406976;
Formula C24H18N4O M. Wt 378.43
  • Biological Activity
Description GO 6976, also known as PD-406976, is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. GO 6976 blocked neurotrophin-induced signaling and autophosphorylation of neurotrophin-specific tyrosine kinase (Trk) receptors, either Trk B in cortical neurons or Trk A in GT1-1-trk9 cells.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets Trk Receptor 

Structure

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