Tenovin-1
| CAS No. | 380315-80-0 | Cat. No. | BCP06745 |
| Name | Tenovin-1 | ||
| Synonyms | Tenovin 1;Tenovin1; | ||
| Formula | C20H23N3O2S | M. Wt | 369.5 |
| Description | Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family. | ||
| Pathways | Cell Cycle/DNA Damage Apoptosis Pathway Epigenetics | ||
| Targets | Sirtuin p53 | ||
Structure
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