BKM-120
| CAS No. | 1202777-78-3 | Cat. No. | BCP06726 |
| Name | BKM-120 | ||
| Synonyms | BKM120; BKM 120; NVP-BKM120; | ||
| Formula | C18H21F3N6O2 | M. Wt | 410.39 |
| Description | BKM120 (NVP-BKM120) is a novel phosphatidylinositol 3-kinase (PI3K) inhibitor and is currently being investigated in phase I clinical trials in solid tumors. Unlike other inhibitors, it does not inhibit the related kinases-mTOR and Vps34. BKM120 (NVP-BKM120) has shown significant cell growth inhibition and induction of apoptosis in a variety of tumor cell lines as well as in animal models, it decreases the cellular levels of p-Akt in mechanistic models and relevant tumor cell lines, as well as d | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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