AG-1024
| CAS号 | 65678-07-1 | 货号 | BCP06692 |
| 中文名 | AG-1024 | ||
| 英文名 | AG-1024 | ||
| 中文别名 | |||
| 英文别名 | AG 1024;AG1024; Tyrphostin AG 1024; | ||
| 分子式 | C14H13BrN2O | 分子量 | 305.17 |
| 生物活性 | AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG1024 decreases Ang II-mediated NAD(P)H oxidase activation. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | IGF1R | ||
结构式
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