Dorsomorphin dihydrochloride
| CAS No. | 1219168-18-9 | Cat. No. | BCP06635 |
| Name | Dorsomorphin dihydrochloride | ||
| Synonyms | Dorsomorphin 2HCl;BML 275 2HCl;BML275 2HCl;BML-275 2HCl; | ||
| Formula | C24H25N5O | M. Wt | 472.41 |
| Description | Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR and Metformin . Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition. | ||
| Related Products | 866405-64-3（Dorsomorphin） | ||
| Pathways | PI3K/Akt/mTOR Epigenetics | ||
| Targets | AMPK | ||
Structure
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