Tirofiban
| CAS No. | 144494-65-5 | Cat. No. | BCP06642 |
| Name | Tirofiban | ||
| Synonyms | MK-383;MK 383;MK383; | ||
| Formula | C22H36N2O5S | M. Wt | 440.6 |
| Description | Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor.It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Integrin | ||
Structure
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