Cobicistat
| CAS No. | 1004316-88-4 | Cat. No. | BCP06630 |
| Name | Cobicistat | ||
| Synonyms | GS 9350;GS9350; GS-9350; | ||
| Formula | C40H53N7O5S2 | M. Wt | 776.03 |
| Description | Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes as a pharmacoenhancer. GS-9350 inhibits CYP3A with IC50 spectrum from 30 nM to 285 nM. In contrast to ritonavir, GS-9350 is devoid of anti-HIV activity, with IC50 of > 30μM against HIV-1 protease and EC50 of > 30μM in MT-2 HIV infection assay, and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential drug-resistant HIV variants. GS-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Cytochrome P450 | ||
Structure
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