Quiflapon
| CAS No. | 136668-42-3 | Cat. No. | BCP06574 |
| Name | Quiflapon | ||
| Synonyms | MK0591;MK 0591;MK-0591; | ||
| Formula | C34H35ClN2O3S | M. Wt | 587.18 |
| Description | MK-0591 is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Research of involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model showed that a novel functional role for 5-lipoxygenase activating protein in the pathogenesis of Alzheimer's disease-like amyloidosis, and suggest that its pharmacological inhibition could provide a novel therapeutic opportunity for Alzheimer's disease. Another research showed 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. |
Structure
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