Lomustine
| CAS No. | 13010-47-4 | Cat. No. | BCP06551 |
| Name | Lomustine | ||
| Synonyms | 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea13010-47-4NCI60_0417431-(2-Chloroethyl)-3-cyclohexylnitrosourea1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-Be; | ||
| Formula | C9H16ClN3O2 | M. Wt | 233.6973 |
| Description | Lomustine inhibits the growth of ZR-75-1 and U373 with IC50 of 12 μM and 15 μM, respectively. Lomustine reduces the level of expression of the DNA repair protein O6-alkylguanine-DNA alkyltransferase.Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2/M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells. | ||
| Pathways | Cell Cycle/DNA Damage Others Pathway | ||
| Targets | DNA Alkylator/Crosslinker Autophagy | ||
Structure
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