Vecuronium bromide

Description	Vecuronium (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. In adolescents the vecuronium requirement was less than in children and was comparable to that reported in adults in other studies (89 +/- 13 micrograms.kg-1.hr-1) . Infusions of Vecuronium provided much smoother control of neuromuscular blockade than did pancuronium. No cardiovascular side-effects were noted even at the greatest dose (0.12 mg kg-1) used. Vecuronium has clear advantages over pancuronium and represents a potentially valuable addition to the armamentarium of clinically useful muscle relaxants. The onset times of the 0.6 and 0.9 mg x kg(-1) of Org 9426 groups were 84.6 and 77.1 sec respectively, which showed statistical difference between the onset time of 0.1 mg x kg(-1) of vecuronium, 125
Pathways	Neuro Signaling Pathway
Targets	nAChR

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