NS309
| CAS No. | 18711-16-5 | Cat. No. | BCP21390 |
| Name | NS309 | ||
| Synonyms | NS 309;NS-309; | ||
| Formula | C8Cl2H4N2O2 | M. Wt | 231.04 |
| Description | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel | ||
Structure
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