BMS-345541 HCl
| CAS No. | 547757-23-3 | Cat. No. | BCP06515 |
| Name | BMS-345541 HCl | ||
| Synonyms | BMS-345541 hydrochloride;BMS345541 hydrochloride;BMS 345541 hydrochloride; | ||
| Formula | C14H17N5.HCl | M. Wt | 291.78 |
| Description | BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). It attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. BMS 345541 also suppresses joint destruction in a mouse model of arthritis. | ||
| Pathways | NFκB | ||
| Targets | IκB/IKK | ||
Structure
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