PQ 401
| CAS No. | 196868-63-0 | Cat. No. | BCP06474 |
| Name | PQ 401 | ||
| Synonyms | PQ401;PQ-401; | ||
| Formula | C18H16ClN3O2 | M. Wt | 341.79 |
| Description | PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | IGF1R | ||
Structure
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