AMD 3465 hexahydrobromide
CAS No. | 185991-07-5 | Cat. No. | BCP06454 |
Name | AMD 3465 hexahydrobromide | ||
Synonyms | AMD3465; AMD3465;AMD-3465; | ||
Formula | C24H38N6.6HBr | M. Wt | 896.07 |
Description | Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100. Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo. | ||
Pathways | GPCR/G Protein | ||
Targets | CXCR |
Structure
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