AMD 3465 hexahydrobromide

  • Chemical Properties
CAS No. 185991-07-5 Cat. No. BCP06454
Name AMD 3465 hexahydrobromide
Synonyms AMD3465; AMD3465;AMD-3465;
Formula C24H38N6.6HBr M. Wt 896.07
  • Biological Activity
Description Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100. Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.
Pathways GPCR/G Protein 
Targets CXCR 

Structure

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