BIX-01294
| CAS No. | 935693-62-2 | Cat. No. | BCP06426 |
| Name | BIX-01294 | ||
| Synonyms | BIX 01294;BIX01294; | ||
| Formula | C28H38N6O2.3HCl.H2O | M. Wt | 618.04 |
| Description | In its inhibition of the histone lysine methyltransferases, BIX-01294 does not compete with cofactor S-adenosyl-methionine. G9a HMTase regulates gene expression including one of the pluripotency genes Oct4. It is reported that BIX-01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors (Oct4, Klf4, Sox2 and c-Myc) were introduced to somatic cells for generation of induced pluripotent stem cells. BIX-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase | ||
Structure
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