GW5074
| CAS No. | 220904-83-6 | Cat. No. | BCP06316 |
| Name | GW5074 | ||
| Synonyms | GW-5074;GW 5074; | ||
| Formula | C15H8Br2INO2 | M. Wt | 520.94 |
| Description | GW5074 is a potent and specific inhibitor of c-Raf with IC50 of 9 nM and has no effect of MKK6, MKK7, p38 MAP kinase and cdks in vitro. However, treatment of neuronal cultures with GW5074 permits accumulation of activating modifications on c-Raf and also B-Raf. The inhibition of LK-induced apoptosis by GW5074 in cerebellar granule neurons is not MEK-ERK-dependent. GW5074 delays down-regulation of Akt activity but inhibits apoptosis by an Akt-independent mechanism. GW5074 affects Ras, nuclear factor-kappa B and c-jun. GW5074 inhibits cell death caused by neurotoxins in granule cells and other neuronal types. | ||
| Pathways | MAPK Pathway | ||
| Targets | Raf | ||
Structure
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