Purvalanol A
| CAS No. | 212844-53-6 | Cat. No. | BCP06309 |
| Name | Purvalanol A | ||
| Synonyms | NG 60;NG-60;NG60;Purvalanol-A; | ||
| Formula | C19H25ClN6O | M. Wt | 388.89 |
| Description | Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | CDK | ||
Structure
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