Indisulam
| CAS号 | 165668-41-7 | 货号 | BCP06110 |
| 中文名 | Indisulam | ||
| 英文名 | Indisulam | ||
| 中文别名 | |||
| 英文别名 | E7070; E 7070; E-7070; ER35744; ER 35744; ER-35744; D04522; | ||
| 分子式 | C14H12ClN3O4S2 | 分子量 | 385.85 |
| 生物活性 | Indisulam, also known as E7070, is a carbonic anhydrase inhbitor, is also a novel synthetic sulfonamide that targets the G1 phase of the cell cycle. The potential antitumor activity of Indisulam was discovered through optimization of the structure-activity relationships of a series of sulfonamide structures. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E. Preclinical studies with Indisulam showed activity in multiple tumor types, most prominently in colon and lung cancer. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Carbonic Anhydrase | ||
结构式
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