Evofosfamide

  • 化学数据
CAS号 918633-87-1 货号 BCP06074
中文名 Evofosfamide
英文名 Evofosfamide
中文别名
英文别名 TH-302;TH 302;TH302;
分子式 C9H16Br2N5O4P 分子量 449.04
  • 用途
生物活性 Evofosfamide, also known as TH-302, is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. Check for active clinical trials or closed clinical trials using this agent.
信号通路 Cell Cycle/DNA Damage 
靶 点 DNA Alkylator/Crosslinker 

结构式

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