Evofosfamide
| CAS号 | 918633-87-1 | 货号 | BCP06074 |
| 中文名 | Evofosfamide | ||
| 英文名 | Evofosfamide | ||
| 中文别名 | |||
| 英文别名 | TH-302;TH 302;TH302; | ||
| 分子式 | C9H16Br2N5O4P | 分子量 | 449.04 |
| 生物活性 | Evofosfamide, also known as TH-302, is a hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity. Check for active clinical trials or closed clinical trials using this agent. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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