GNE-493
| CAS No. | 1033735-94-2 | Cat. No. | BCP06045 |
| Name | GNE-493 | ||
| Synonyms | GNE493;GNE 493; | ||
| Formula | C17H20N6O2S | M. Wt | 372.44 |
| Description | GNE-493 has good pharmacokinetic (PK) parameters, GNE-493 is highly selective, demonstrate knock down of pathway markers in vivo, and are efficacious in xenograft models where the PI3K pathway is deregulated. GNE-493 was compared in a PI3KR mutated MCF7.1 xenograft model and were found to have equivalent efficacy when normalized for exposure. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K mTOR | ||
Structure
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