Tideglusib
| CAS No. | 865854-05-3 | Cat. No. | BCP06016 |
| Name | Tideglusib | ||
| Synonyms | NP-12;NP031112;NP 031112;NP-031112; | ||
| Formula | C19H14N2O2S | M. Wt | 334.39 |
| Description | Tideglusib irreversibly inhibits GSK-3, reduces tau phosphorylation, and prevents apoptotic death in human neuroblastoma cells and murineprimary neurons.Tideglusib (2.5 μM) inhibits glutamate-induced glial activation as evidenced by decreased TNF-α and COX-2 expression in rat primary astrocyte or microglial cultures. Tideglusib (2.5 μM) also exerts a potent neuroprotective effect on cortical neurons from glutamate-induced excitotoxicity as evidenced by significant reduction in the number of Annexin-V-positive cells in rat primary astrocyte or microglial cultures. | ||
| Pathways | Wnt/Stem Cell PI3K/Akt/mTOR | ||
| Targets | GSK3 | ||
Structure
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