Apalutamide

  • Chemical Properties
CAS No. 956104-40-8 Cat. No. BCP05829
Name Apalutamide
Synonyms ARN 509; ARN509;AR-509;JNJ56021927; JNJ-56021927;JNJ 56021927;
Formula C21H15F4N5O2S M. Wt 477.43
  • Biological Activity
Description Apalutamide, also known as ARN-509 and JNJ-56021927 , is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.
Pathways Hormone Pathay 
Targets Androgen Receptor  

Structure

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