吉西他滨单磷酸酯
| CAS号 | 116371-67-6 | 货号 | BCP21656 |
| 中文名 | 吉西他滨单磷酸酯 | ||
| 英文名 | Gemcitabine Monophosphate | ||
| 中文别名 | |||
| 英文别名 | 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid; | ||
| 分子式 | C9H12F2N3O7P | 分子量 | 343.18 |
| 生物活性 | Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. GemMP decreased tumor cell growth at concentrations ranging from 1 to 50 nM. GemMP is a potent cytotoxic agent that serves to induce apoptosis in association with increased Fas expression in cultured thyroid cancer cell lines. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis Antimetabolite | ||
结构式
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