GSK2636771
| CAS No. | 1372540-25-4 | Cat. No. | BCP05688 |
| Name | GSK2636771 | ||
| Synonyms | GSK 2636771;GSK-2636771; | ||
| Formula | C22H22F3N3O3 | M. Wt | 433.42 |
| Description | GSK-2636771 shows selectively inhibitory activity in PTEN null cell lines (human prostate adenocarcinoma PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. GSK2636771 significantly decreases cell viability in p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines, and leads to a marked decrease of AKT phosphorylation only in the control prostate and breast cancer cell lines. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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