(+)-MK 801 Maleate

CAS No.	77086-22-7	Cat. No.	BCP21811
Name	(+)-MK 801 Maleate
Synonyms	Dizocilpine maleate;Dizocilpine hydrogen maleate;(+)-MK 801;MK 801;
Formula	C20H19NO4	M. Wt	337.37

Description	(+)-MK 801 (Maleate) is an uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug acts as a potent anti-convulsant and likely has dissociative anesthetic properties, but it is not used clinically for this purpose due to the discovery of brain lesions, called Olney's lesions (see below), in test rats. Dizocilpine is the most frequently used non-competitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.
Pathways	Ion Channel/Membrane Transporter
Targets	AMPA/NMDA

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