MLN0905
| CAS No. | 1228960-69-7 | Cat. No. | BCP05348 |
| Name | MLN0905 | ||
| Synonyms | PLK1 Inhibitor;MLN 0905;MLN-0905; | ||
| Formula | C24H25F3N6S | M. Wt | 486.56 |
| Description | MLN0905 is a potent inhibitor of PLK1 with IC50 of 2 nM. MLN0905 inhibits cell mitosis with EC50 of 9 nM. MLN0905 inhibits Cdc25C-T96 phosphorylation, a direct readout of PLK1 inhibition with EC50 of 29 nM. MLN0905 inhibits HT-29 viability with LD50 of 22 nM. MLN0905 possesses reasonable selectivity against a panel of 359 kinases.MLN0905 inhibits a panel of lymphoma cells viability with IC50 of 3 – 24 nM. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PLK | ||
Structure
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