Bafetinib
| CAS No. | 859212-16-1 | Cat. No. | BCP22045 |
| Name | Bafetinib | ||
| Synonyms | INNO406; INNO-406; INNO 406; NS187; NS-187; NS 187; | ||
| Formula | C30H31F3N8O | M. Wt | 576.61 |
| Description | Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl | ||
Structure
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