Tasisulam
| CAS No. | 519055-62-0 | Cat. No. | BCP05154 |
| Name | Tasisulam | ||
| Synonyms | LY573636; LY 573636; LY-573636; | ||
| Formula | C11H6BrCl2NO3S2 | M. Wt | 415.11 |
| Description | Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death; shows antiproliferative effect against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines; promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation; causes aberrant pre-mRNA splicing. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | E1 E2 E3 Enzyme | ||
Structure
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