Domiphen bromide
| CAS No. | 538-71-6 | Cat. No. | BCP04904 |
| Name | Domiphen bromide | ||
| Synonyms | Domiphen Br; | ||
| Formula | C22H40BrNO | M. Wt | 414.46 |
| Description | Domiphen bromide is a quaternary antiseptic used as an antifungal agent. Domiphen bromide has potent activity on blockade of human ether-a-go-go related gene (HERG) channels. Domiphen bromide inhibited HERG channel currents in a dose-dependent manner with IC50 values of 9nM. Block of HERG channel by domiphen bromide was voltage-dependent and use-dependent. Domiphen bromide caused substantial negative shift of the activation curves, accelerated activated process, but had no effects on the deactivation and reactivation processes. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel | ||
Structure
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