Micafungin Sodium

Description	in vitro: MCFG is also not active against deoxyribonucleic acid, ribonucleic acid or protein synthesis in C. albicans ATCC 90028 (IC50 s were both over 100 .MU.g/mL) . The effect of an optimal therapeutic dose of 10?mg?ml-1 micafungin on the production of biofilm was monitored in vitro using a microtiter plate assay. For all the genes tested, the levels of mRNA transcription were also decreased significantly (p?0.05) in micafungin-treated samples cf. their untreated counterparts. in vivo: In a mouse model of septic A. fumigatus infection, although non-treated mice survived for a maximum of only 6 days, the survival rate of micafungin-treated mice (0.1?mg?kg-1) increased to 20%, while the survival rate of mice treated with a combination of micafungin (0.1?mg?kg-1) and KB425796-C (32?mg?kg-1) increased to 100% during the 31-day post-infection period.
Pathways	Microbiology/Virology
Targets	Antifungal

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