Doxapram hydrochloride monohydrate
| CAS No. | 7081-53-0 | Cat. No. | BCP04771 |
| Name | Doxapram hydrochloride monohydrate | ||
| Synonyms | Dopram hydrochloride hydrate; Stimulex hydrochloride hydrate; Respiram hydrochloride hydrate; | ||
| Formula | C24H30N2O2.ClH.H2O | M. Wt | 432.99 |
| Description | Doxapram inhibits both TASK-1 and TASK-3 function in a dose dependent manner. Doxapram inhibition at both hyperpolarized and depolarized potentials, as well as effects independent of extracellular potassium concentration. It is said that the carboxy terminal domain of TASK-1 is important to doxapram inhibition. Doxapram also inhibits TRESK, TASK-2, and TREK-1 but at significantly larger concentrations (EC50s of 240 μM, 460 μM, and >1 mM, respectively. Doxapram has no effect on MAC for halothane. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel | ||
Structure
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