Afimoxifene

CAS No.	68392-35-8	Cat. No.	BCP04749
Name	Afimoxifene
Synonyms	4-Monohydroxytamoxifen;4-OHT; 4-HT; OHTAM;4-Hydroxytamoxifen;Hydroxytamoxifen;trans-4-Hydroxytamoxifen; Tamoxifen metabolite B;
Formula	C26H29NO2	M. Wt	387.51

Description	Afimoxifene (4-hydroxytamoxifen) is a selective estrogen receptor modulator which is the active metabolite of tamoxifen. Afimoxifene is a transdermal gel formulation and is being developed by Ascend Therapeutics, Inc. under the trademark TamoGel. Afimoxifene has completed a phase II clinical trial for the treatment of cyclical mastalgia. A study in France on 55 women showed that rubbing afimoxifene on the skin was as good as tamoxifen tablets at slowing breast cancer growth. A US trial will compare 6 weeks use before breast cancer surgery. Skin application can reduce systemic levels by a factor of nine and this is expected to reduce the unpleasant side-effects of tamoxifen.
Pathways	Hormone Pathay
Targets	Estrogen Receptor

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