AT406
| CAS No. | 1071992-99-8 | Cat. No. | BCP04668 |
| Name | AT406 | ||
| Synonyms | DeBio-1143; DeBio1143; DeBio 1143;SM-406;AT406;AT 406;SM406;SM 406;ARRY-334543; ARRY334543; ARRY 334543; | ||
| Formula | C32H43N5O4 | M. Wt | 561.71 |
| Description | This may restore and promote the induction of apoptosis through apoptotic signaling pathways. AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains. AT-406 is currently in Phase I clinical trial in patients with advanced solid tumors and lymphomas. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | IAP | ||
Structure
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