Sitagliptin phosphate
| CAS No. | 654671-78-0 | Cat. No. | BCP04564 |
| Name | Sitagliptin phosphate | ||
| Synonyms | MK-0431 phosphate;MK 0431 phosphate;MK0431 phosphate; | ||
| Formula | C16H15F6N5O.H3PO4 | M. Wt | 505.31 |
| Description | Sitagliptin phosphate is a potent inhibitor of DPP4 in Caco-2 cell extracts.As an orally active agent, Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts. MK0431 reduces in vitro migration of isolated splenic CD4 T-cells through a pathway involving cAMP/PKA/Rac1 activation.A recent study demonstrates that sitagliptin exerts a novel, direct action in order to stimulate GLP-1 secretion by the intestinal L cell through a DPP-4-independent, protein kinase A- and MEK-ERK1/2-dependent pathway. It therefore reduces the effect of autoimmunity on graft survival. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | DPP | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.