PF670462
| CAS号 | 950912-80-8 | 货号 | BCP04305 |
| 中文名 | PF670462 | ||
| 英文名 | PF670462 | ||
| 中文别名 | |||
| 英文别名 | PF 670462;PF-670462; | ||
| 分子式 | C19H20FN5.2HCl | 分子量 | 410.32 |
| 生物活性 | PF-670462 has been proved to be both a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations; in transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo. | ||
| 信号通路 | Cell Cycle/DNA Damage Wnt/Stem Cell | ||
| 靶 点 | Casein Kinase | ||
结构式
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