Naratriptan hydrochloride

CAS No.	143388-64-1	Cat. No.	BCP04270
Name	Naratriptan hydrochloride
Synonyms	Naratriptan HCl;Amerge hydrochloride;GR-85548A hydrochloride;Naramig hydrochloride;
Formula	C17H25N3O2S.HCl	M. Wt	371.93

Description	Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	5 HT Receptor/Serotonin Receptor

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