康普瑞汀A4
CAS号 | 117048-59-6 | 货号 | BCP04204 |
中文名 | 康普瑞汀A4 | ||
英文名 | Combretastatin A4 | ||
中文别名 | 考布他汀A4; | ||
英文别名 | NSC-817373;NSC 817373;CRC 87-09;CA4DP;Combretastatin A-4;(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol;CRC-87-09; | ||
分子式 | C18H20O5 | 分子量 | 316.35 |
生物活性 | Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM,and an antitumor, antiangiogenic and antimetastatic agent.Combrestatin A4 is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer). | ||
信号通路 | Cell Cycle/DNA Damage | ||
靶 点 | Microtubule |
结构式
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