Skepinone-L
| CAS No. | 1221485-83-1 | Cat. No. | BCP04105 |
| Name | Skepinone-L | ||
| Synonyms | Skepinone L; | ||
| Formula | C24H21F2NO4 | M. Wt | 425.42 |
| Description | Skepinone-L shows concentration-dependent inhibition of HSP27 (Ser82) phosphorylation through the p38 MAPK pathway with a cellular IC50 of approximately 25 nM, and also reduces concentrations of TNF-α, IL-1β and IL-10, regulated by p38 MAPK, with IC50 ranging from 30 to 50 nM .Skepinone-L (1 μM) abrogates the phosphorylation of platelet p38 MAPK substrate Hsp27 activated by stimulation with CRP, thrombin or thromboxane A2 analogue U-46619, and impairs platelet secretion and aggregation. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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