Apremilast
| CAS No. | 608141-41-9 | Cat. No. | BCP03783 |
| Name | Apremilast | ||
| Synonyms | CC 10004;CC10004;CC-10004; | ||
| Formula | C22H24N2O7S | M. Wt | 460.5 |
| Description | Apremilast is more potent for inhibition of PDE4 compared with cAMP or cGMP hydrolysing enzymes from other PDE families. Apremilast displays a broad pattern of anti-inflammatory activity in a variety of cell types, inhibits TNF-α, IL-12 and IL-23 production, as well as NK and keratinocyte responses. Apremilast is found to inhibit the zymosan-induced PMN production of IL-8 with IC50 of 94 nM. Apremilast inhibits fMLF-induced PMN CD18 and CD11b expression with IC50 of 390 nM and 74 nM, respectively, and inhibits fMLF-induced adhesion of PMN to HUVECs with IC50 of 150 nM. Apremilast inhibits keratinocyte TNF-αproduction, with no effect on keratinocyte cell viability as measured by intracellular ATP levels. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphodiesterase/PDE | ||
Structure
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